Regulation of splicing by SR proteins and SR protein-specific kinases

Regulation of splicing-associated SR proteins by HPV-16.

HPV-16 (human papillomavirus type 16) is a small dsDNA (double-stranded DNA) virus which infects mucosal epithelial tissue of the cervix. Epithelial tissue is composed of a basal layer of cells, capable of division, and a number of suprabasal layers, wherein the cells become more differentiated the closer to the surface of the epithelium they become. Expression of viral proteins is dependent up...

Regulation of alternative splicing of CD45 by antagonistic effects of SR protein splicing factors.

CD45 is a transmembrane glycoprotein possessing tyrosine phosphatase activity, which is involved in cell signaling. CD45 is expressed on the surface of most leukocytes and can be alternatively spliced by the inclusion or skipping of three variable exons (4, 5, and 6 or A, B, and C) to produce up to eight isoforms. In T cells, the splicing pattern of CD45 isoforms changes after activation; naive...

Factors Antagonistic Effects of SR Protein Splicing Regulation of Alternative Splicing of CD45 by

THE ROLE OF SR AND SR‐RELATED PROTEINS IN pre‐mRNA SPLICING

Pre‐mRNA splicing requires the activities of small nuclear ribonucleoproteins and other essential splicing factors. Among these are members of the SR protein family and SR‐related proteins, which are integrally involved in regulating exon recognition, spliceosomal assembly, and spliceosomal re‐arrangements to promote intron excision. This chapter will focus on the discovery of SR proteins and S...

Human papillomavirus regulation of SR proteins.

Splicing is a cellular process essential for mRNA biogenesis. There are two types of splicing: constitutive and alternative splicing. During constitutive splicing, non-coding intron sequences are removed and exonic coding sequences are spliced together to form mature mRNAs. Alternative splicing can maximize the coding capacity of the genome by specific alternative selection of exons from multi-...